Progressive Cutaneous Herpes Simplex Infection in Acute Myeloblastic Leukemia: Successful Treatment With Interferon and Cytarabine

Yoseph Shalev, Alain Berrebi, Leslie Green, Stanley Levin, Azriel Frumkin, Nina Hurwitz, Zvi Bentwich

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A patient had acute myeloblastic leukemia and extensive progressive cutaneous herpes simplex virus infection. Complete and rapid healing of skin lesions with remission of the leukemia occurred during 15 days of therapy with human leukocyte interferon and minimal doses of cytarabine hydrochloride. Pharmacokinetic studies showed that the patient had a defective antiviral interferon response, which was effectively corrected by treatment with interferon alpha. This may help to explain the dramatic response of both conditions to therapy.

Original languageEnglish
Pages (from-to)922-926
Number of pages5
JournalArchives of Dermatology
Volume120
Issue number7
DOIs
StatePublished - 1 Jan 1984
Externally publishedYes

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