Progressive Cutaneous Herpes Simplex Infection in Acute Myeloblastic Leukemia: Successful Treatment With Interferon and Cytarabine

Yoseph Shalev; Alain Berrebi; Leslie Green; Stanley Levin; Azriel Frumkin; Nina Hurwitz; Zvi Bentwich

doi:10.1001/archderm.1984.01650430108020

Progressive Cutaneous Herpes Simplex Infection in Acute Myeloblastic Leukemia: Successful Treatment With Interferon and Cytarabine

Yoseph Shalev, Alain Berrebi, Leslie Green, Stanley Levin, Azriel Frumkin, Nina Hurwitz, Zvi Bentwich

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A patient had acute myeloblastic leukemia and extensive progressive cutaneous herpes simplex virus infection. Complete and rapid healing of skin lesions with remission of the leukemia occurred during 15 days of therapy with human leukocyte interferon and minimal doses of cytarabine hydrochloride. Pharmacokinetic studies showed that the patient had a defective antiviral interferon response, which was effectively corrected by treatment with interferon alpha. This may help to explain the dramatic response of both conditions to therapy.

Original language	English
Pages (from-to)	922-926
Number of pages	5
Journal	Archives of Dermatology
Volume	120
Issue number	7
DOIs	https://doi.org/10.1001/archderm.1984.01650430108020
State	Published - 1 Jan 1984
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1001/archderm.1984.01650430108020

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title = "Progressive Cutaneous Herpes Simplex Infection in Acute Myeloblastic Leukemia: Successful Treatment With Interferon and Cytarabine",

abstract = "A patient had acute myeloblastic leukemia and extensive progressive cutaneous herpes simplex virus infection. Complete and rapid healing of skin lesions with remission of the leukemia occurred during 15 days of therapy with human leukocyte interferon and minimal doses of cytarabine hydrochloride. Pharmacokinetic studies showed that the patient had a defective antiviral interferon response, which was effectively corrected by treatment with interferon alpha. This may help to explain the dramatic response of both conditions to therapy.",

author = "Yoseph Shalev and Alain Berrebi and Leslie Green and Stanley Levin and Azriel Frumkin and Nina Hurwitz and Zvi Bentwich",

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T2 - Successful Treatment With Interferon and Cytarabine

AU - Shalev, Yoseph

AU - Berrebi, Alain

AU - Green, Leslie

AU - Levin, Stanley

AU - Frumkin, Azriel

AU - Hurwitz, Nina

AU - Bentwich, Zvi

PY - 1984/1/1

Y1 - 1984/1/1

N2 - A patient had acute myeloblastic leukemia and extensive progressive cutaneous herpes simplex virus infection. Complete and rapid healing of skin lesions with remission of the leukemia occurred during 15 days of therapy with human leukocyte interferon and minimal doses of cytarabine hydrochloride. Pharmacokinetic studies showed that the patient had a defective antiviral interferon response, which was effectively corrected by treatment with interferon alpha. This may help to explain the dramatic response of both conditions to therapy.

AB - A patient had acute myeloblastic leukemia and extensive progressive cutaneous herpes simplex virus infection. Complete and rapid healing of skin lesions with remission of the leukemia occurred during 15 days of therapy with human leukocyte interferon and minimal doses of cytarabine hydrochloride. Pharmacokinetic studies showed that the patient had a defective antiviral interferon response, which was effectively corrected by treatment with interferon alpha. This may help to explain the dramatic response of both conditions to therapy.

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DO - 10.1001/archderm.1984.01650430108020

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Progressive Cutaneous Herpes Simplex Infection in Acute Myeloblastic Leukemia: Successful Treatment With Interferon and Cytarabine

Abstract

ASJC Scopus subject areas

UN SDGs

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