Prolactin - Not Only a "Milk Hormone" Prolactin - Growth Hormone Relationships with Emphasis on Cancer

Alon Farfel; Haim Werner; Zvi Laron

doi:10.17458/per.vol15.2018.fwl.prolactinrelationshipscancer

Prolactin - Not Only a "Milk Hormone" Prolactin - Growth Hormone Relationships with Emphasis on Cancer

Alon Farfel, Haim Werner, Zvi Laron

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Prolactin (PRL) is a hormone secreted by lactotrophic cells in the anterior pituitary gland and its main function is the stimulation of lactogenesis. Research in recent years has revealed that PRL is also related to cancer development and plays a role in autoimmune diseases. PRL and Growth Hormone (GH) belong to the same cytokine family, both are, at least in part, secreted by the same somatomammotrophic cells in the anterior pituitary, and share similar signaling pathways. These common features raise the question whether PRL and GH share also joint actions especially in the pathogenesis of cancer.

Original language	English
Pages (from-to)	216-222
Number of pages	7
Journal	Pediatric Endocrinology Reviews
Volume	15
Issue number	3
DOIs	https://doi.org/10.17458/per.vol15.2018.fwl.prolactinrelationshipscancer
State	Published - 1 Mar 2018

Keywords

Cancer
Growth hormone
IGF
Lactogenic hormone
Prolactin

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.17458/per.vol15.2018.fwl.prolactinrelationshipscancer

Cite this

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AB - Prolactin (PRL) is a hormone secreted by lactotrophic cells in the anterior pituitary gland and its main function is the stimulation of lactogenesis. Research in recent years has revealed that PRL is also related to cancer development and plays a role in autoimmune diseases. PRL and Growth Hormone (GH) belong to the same cytokine family, both are, at least in part, secreted by the same somatomammotrophic cells in the anterior pituitary, and share similar signaling pathways. These common features raise the question whether PRL and GH share also joint actions especially in the pathogenesis of cancer.

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Prolactin - Not Only a "Milk Hormone" Prolactin - Growth Hormone Relationships with Emphasis on Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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