Properties and Function of the Solute Carrier 26 Family of Anion Transporters

Nikolay Shcheynikov, Ehud Ohana, Shmuel Muallem

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The SLC26 family of anion transporters consists of 10 members that display remarkable functional and substrate diversity. Mutations in several members of the family have been identified as causing a variety of human diseases and mouse phenotype when deleted. The family drew the attention and strong interest of epithelial biologist with the identification of the first elusive luminal Cl−/HCO3− exchange, which turned to be the third member of the family SLC26A3. Fairly quick, progress since revealed that members of the family transport all halides, NO3−, SO42−, oxalate, and formate, among others. Members of the family can be grouped into three subgroups based on substrate selectivity and transport mode: the SO42− transporters SLC26A1 and SLC26A2; the anion exchangers 2Cl−/1HCO3− SLC26A3, 1Cl−/1HCO3− SLC26A4, and 1Cl−/2HCO3− SLC26A6; and the Cl− channels SLC26A7, SLC26A9, and SLC26A11. This chapter discusses structural features, transport properties, and regulation of the transporters that are essential to understand their functions and roles in human diseases.

Original languageEnglish
Title of host publicationIon Channels and Transporters of Epithelia in Health and Disease
EditorsKirk L. Hamilton, Daniel C. Devor
PublisherSpringer
Pages465-489
Number of pages25
StatePublished - 2016

Publication series

NamePhysiology in Health and Disease
ISSN (Print)2625-252X
ISSN (Electronic)2625-2538

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