Prophylactic Administration of Tranexamic Acid Reduces Blood Products’ Transfusion and Intensive Care Admission in Women Undergoing High-Risk Cesarean Sections

Yair Binyamin, Amit Frenkel, Igor Gruzman, Sofia Lerman, Yoav Bichovsky, Alexander Zlotnik, Michael Y. Stav, Offer Erez, Sharon Orbach-Zinger

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Postpartum hemorrhage (PPH) remains a major cause of maternal mortality. Tranexamic acid (TxA) has shown effectiveness in reducing PPH-related maternal bleeding events and deaths. We conducted a cohort study including parturient women at high risk of bleeding after undergoing a cesarean section (CS). Participants were divided into two groups: the treatment group received prophylactic 1-g TxA before surgery (n = 500), while the comparison group underwent CS without TxA treatment (n = 500). The primary outcome measured increased maternal blood loss following CS, defined as more than a 10% drop in hemoglobin concentration within 24 h post-CS and/or a drop of ≥2 g/dL in maternal hemoglobin concentration. Secondary outcomes included PPH indicators, ICU admission, hospital stay, TxA complications, and neonatal data. TxA administration significantly reduced hemoglobin decrease by more than 10%: there was a 35.4% decrease in the TxA group vs. a 59.4% decrease in the non-TxA group, p < 0.0001 and hemoglobin decreased by ≥2 g/dL (11.4% in the TxA group vs. 25.2% in non-TxA group, p < 0.0001), reduced packed red blood cell transfusion (p = 0.0174), and resulted in lower ICU admission rates (p = 0.034) and shorter hospitalization (p < 0.0001). Complication rates and neonatal outcomes did not differ significantly. In conclusion, prophylactic TxA administration during high-risk CS may effectively reduce blood loss, providing a potential intervention to improve maternal outcomes.

Original languageEnglish
Article number5253
JournalJournal of Clinical Medicine
Volume12
Issue number16
DOIs
StatePublished - 1 Aug 2023

Keywords

  • cesarean section
  • hemoglobin
  • hysterectomy
  • post-partum hemorrhage
  • prevention
  • prophylaxis
  • renal failure
  • tranexamic acid

ASJC Scopus subject areas

  • General Medicine

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