Prophylactic treatment of asthma by an ozone scavenger in a mouse model

Haim Bibi, Ofer Reany, Dan Waisman, Ehud Keinan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Our hypothesis that inflammation in asthma involves production of ozone by white blood cells and that ozone could be an inflammatory mediator suggests that scavengers of reactive oxygen species (ROS), for example, electron-rich olefins, could serve for prophylactic treatment of asthma. Olefins could provide chemical protection against either exogenous or endogenous ozone and other ROS. BALB/c mice pretreated by inhalation of d-limonene before an ovalbumin challenge exhibited significant attenuation of the allergic asthma symptoms. Diminution of the inflammatory process was evident by reduced levels of aldehydes, reduced counts of neutrophils in the BAL fluid and by histological tests. A surprising systemic effect was observed by decreased levels of aldehydes in the spleen, suggesting that the examination of tissues and organs that are remote from the inflammation foci could provide valuable information on the distribution of the oxidative stress and may serve as guide for targeted treatment.

Original languageEnglish
Pages (from-to)342-346
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number2
DOIs
StatePublished - 15 Jan 2015

Keywords

  • Aldehyde biomarkers
  • Asthma
  • Respiratory inflammation
  • Systemic oxidative stress
  • d-Limonene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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