Prophylactic use of chlorpromazine to improve survival of random skin flaps in pigs

A. Sagi, R. Bibi, M. Ferder, B. Strauch

Research output: Contribution to journalArticlepeer-review


On the basis of earlier success in rat studies, chlorpromazine was evaluated as a probable agent for improving survival of random skin flaps in pigs. The aim was to exclude the possibility that the effect of the chlorpromazine is species specific and to find out if it is dose dependent. One hundred and five dorsally-based 12 x 4 cm flaps were raised unilaterally on the backs of 15 pigs. The animals were divided into three groups using 15 mg/kg chlorpromazine, 7.5 mg/kg chlorpromazine, and a saline-treated control group. Flaps in the control group averaged 40.57 ± 3.17% necrosis, while flaps in the 15 mg/kg and 7.5 mg/kg chlorpromazine-treated groups averaged 31.53 ± 4.77% and 11.47 ± 2.22% necrosis respectively. These results demonstrate dose dependent beneficial affects of chlorpromazine and the survival of random skin flaps in the pig. Although ideal dose levels are still to be determined, flap survival improved with the prophylactic use of chlorpromazine at the lower 7.5 mg/kg dosage.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalEuropean Journal of Plastic Surgery
Issue number2
StatePublished - 1 Mar 1997


  • Chlorpromazine
  • Flap necrosis

ASJC Scopus subject areas

  • Surgery


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