Prospective longitudinal investigation shows correlation of event-related potential to mild traumatic brain injury in adolescents

Offir Laufer, Amir Geva, Jonathan D. Ellis, Kim Barber Foss, Maayan Ettinger, Yaki Stern, Todd Arthur, Jeffrey Kutcher, Gregory Myer, Amit Reches

Research output: Contribution to journalArticlepeer-review

Abstract

Study Design: Prospective longitudinal cohort study Background: Adolescent athletes may be more susceptible to the long-term effects of mild traumatic brain injury (mTBI). A diagnostic and prognostic neuromarker may optimize management and return-to-activity decision-making in athletes who experience mTBI. Objective: Measure an event-related potential (ERP) component captured with electroencephalography (EEG), called processing negativity (PN), at baseline and post-injury in adolescents who suffered mTBI and determine their longitudinal response relative to healthy controls. Methods: Thirty adolescents had EEG recorded during an auditory oddball task at a pre-mTBI baseline session and subsequent post-mTBI sessions. Longitudinal EEG data from patients and healthy controls (n= 77) were obtained from up to four sessions in total and processed using Brain Network Analysis algorithms. Results: The average PN amplitude in healthy controls significantly decreased over sessions 2 and 3; however, it remained steady in the mTBI group’s 2nd (post-mTBI) session and decreased only in sessions 3 and 4. Pre- to post-mTBI amplitude changes correlated with the time interval between sessions. Conclusion: These results demonstrate that PN amplitude changes may be associated with mTBI exposure and subsequent recovery in adolescent athletes. Further study of PN may lead to it becoming a neuromarker for mTBI prognosis and return-to-activity decision-making in adolescents.

Original languageEnglish
Pages (from-to)871-880
Number of pages10
JournalBrain Injury
Volume34
Issue number7
DOIs
StatePublished - 6 Jun 2020
Externally publishedYes

Keywords

  • Event-related potential
  • concussion
  • neuroscience

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