Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome

Morey Schachter, Arieh Raziel, Devorah Strassburger, Carmela Rotem, Raphael Ron-El, Shevach Friedler

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

One hundred and two women with insulin-resistant polycystic ovary syndrome were randomized to treatment with a vitamin B preparation, metformin, or both, in conjunction with standard infertility treatment. Plasma homocysteine levels were significantly reduced by both B vitamins and metformin, but to a greater degree by B vitamins, and higher pregnancy rates were associated with vitamin B treatment.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalFertility and Sterility
Volume88
Issue number1
DOIs
StatePublished - 1 Jul 2007
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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