TY - JOUR
T1 - Prostaglandin release by normal and osteomyelitic human bones
AU - Plotquin, D.
AU - Dekel, S.
AU - Katz, S.
AU - Danon, A.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - The release of prostaglandin E (PGE) and prostacyclin (as 6-keto PGF1α) by human osteomyelitic bone, compared with normal (control) bone, incubated in vitro was evaluated. Prostacyclin was the main arachidonic acid metabolite released by normal human bone, and similar quantities were released by osteomyelitic bone. However, PGE production was 5-30-fold higher in osteomyelitic bone, compared with control, thus becoming the major prostanoid in this disease. It is concluded that PGE production is probably involved in the inflammatory and/or bone resorption processes that occur in osteomyelitis.
AB - The release of prostaglandin E (PGE) and prostacyclin (as 6-keto PGF1α) by human osteomyelitic bone, compared with normal (control) bone, incubated in vitro was evaluated. Prostacyclin was the main arachidonic acid metabolite released by normal human bone, and similar quantities were released by osteomyelitic bone. However, PGE production was 5-30-fold higher in osteomyelitic bone, compared with control, thus becoming the major prostanoid in this disease. It is concluded that PGE production is probably involved in the inflammatory and/or bone resorption processes that occur in osteomyelitis.
UR - http://www.scopus.com/inward/record.url?scp=0025843545&partnerID=8YFLogxK
U2 - 10.1016/0952-3278(91)90126-P
DO - 10.1016/0952-3278(91)90126-P
M3 - Article
C2 - 1881938
AN - SCOPUS:0025843545
SN - 0952-3278
VL - 43
SP - 13
EP - 15
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 1
ER -