Protection of guinea pigs against cutaneous leishmaniasis by combined infection and chemotherapy

J. El-On, A. Witztum, L. F. Schnur

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A paromomycin and methylbenzethonium chloride ointment cured Leishmania enriettii infections in guinea pigs. Amastigotes were totally eliminated from the treated lesion after 10 days of treatment. A delayed effect also occurred on untreated lesions in the same animals. Lesions treated at various times after infection permitted protective immunity to develop, and 90% of treated animals were refractory to reinfection.

Original languageEnglish
Pages (from-to)704-706
Number of pages3
JournalInfection and Immunity
Volume51
Issue number2
DOIs
StatePublished - 1 Jan 1986
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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