Protein kinase Cθ: A new essential superstar on the T-cell stage

Amnon Altman, Noah Isakov, Gottfried Baier

Research output: Contribution to journalReview articlepeer-review

138 Scopus citations


Recent studies have identified protein kinase Cθ (PKCθ), a member of the Ca2+-independent PKC family, as an essential component of the T-cell synapse that cooperates with calcineurin to activate the interleukin-2 (IL-2) gene. Several selective functions of PKCθ involved in the activation and survival of T cells are reviewed herein. Among these, the nuclear factor-≃B (NF-≃B) signaling cascade appears to be the most critical target of PKCθ in the T-cell receptor/CD28 costimulatory pathway that leads to T-cell activation.

Original languageEnglish
Pages (from-to)567-573
Number of pages7
JournalImmunology Today
Issue number11
StatePublished - 18 Dec 2000

ASJC Scopus subject areas

  • Immunology


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