Protein kinase C theta: a new essential superstar on the T-cell stage

A Altman, N Isakov, G Baier

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent studies have identified protein kinase Cθ (PKCθ), a member of the Ca2+-independent PKC family, as an essential component of the T-cell synapse that cooperates with calcineurin to activate the interleukin-2 (IL-2) gene. Several selective functions of PKCθ involved in the activation and survival of T cells are reviewed herein. Among these, the nuclear factor-κB (NF-κB) signaling cascade appears to be the most critical target of PKCθ in the T-cell receptor/CD28 costimulatory pathway that leads to T-cell activation.
Original languageEnglish GB
Pages (from-to)567-573
JournalImmunology Today
Volume21
Issue number11
DOIs
StatePublished - Nov 2000

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