Protein kinase C-theta in platelet activation

Sagit Cohen; Alex Braiman; George Shubinsky; Noah Isakov

doi:10.1016/j.febslet.2011.09.014

Protein kinase C-theta in platelet activation

Sagit Cohen, Alex Braiman, George Shubinsky, Noah Isakov

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Members of the protein kinase C (PKC) family of serine/threonine kinases have been implicated in several physiological processes regulating the activation response of platelets. They are involved in processes leading to granule secretion, integrin activation, platelet aggregation and spreading, and procoagulation. The protein kinase C θ (PKCθ) isoform, which was originally identified in T lymphocytes, is also expressed at relatively high levels in platelets, wherein it is involved in the regulation of hemostasis and thrombosis. Recent studies suggest a role for PKCθ in protease-activated receptor (PAR)-, glycoprotein VI (GPVI) receptor- and glycoprotein α _IIbβ ₃ integrin receptor-linked signal transduction pathways. The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation.

Original language	English
Pages (from-to)	3208-3215
Number of pages	8
Journal	FEBS Letters
Volume	585
Issue number	20
DOIs	https://doi.org/10.1016/j.febslet.2011.09.014
State	Published - 20 Oct 2011

Keywords

α-Granules
Aggregation
CD62P
Hemostasis
P-selectin
PAR4
Platelets
Protein kinase C θ
Signal transduction
Thrombin
Thrombus formation

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2011.09.014

Cite this

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title = "Protein kinase C-theta in platelet activation",

abstract = "Members of the protein kinase C (PKC) family of serine/threonine kinases have been implicated in several physiological processes regulating the activation response of platelets. They are involved in processes leading to granule secretion, integrin activation, platelet aggregation and spreading, and procoagulation. The protein kinase C θ (PKCθ) isoform, which was originally identified in T lymphocytes, is also expressed at relatively high levels in platelets, wherein it is involved in the regulation of hemostasis and thrombosis. Recent studies suggest a role for PKCθ in protease-activated receptor (PAR)-, glycoprotein VI (GPVI) receptor- and glycoprotein α IIbβ 3 integrin receptor-linked signal transduction pathways. The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation.",

keywords = "α-Granules, Aggregation, CD62P, Hemostasis, P-selectin, PAR4, Platelets, Protein kinase C θ, Signal transduction, Thrombin, Thrombus formation",

author = "Sagit Cohen and Alex Braiman and George Shubinsky and Noah Isakov",

year = "2011",

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doi = "10.1016/j.febslet.2011.09.014",

language = "English",

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journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Wiley-Blackwell",

number = "20",

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T1 - Protein kinase C-theta in platelet activation

AU - Cohen, Sagit

AU - Braiman, Alex

AU - Shubinsky, George

AU - Isakov, Noah

PY - 2011/10/20

Y1 - 2011/10/20

N2 - Members of the protein kinase C (PKC) family of serine/threonine kinases have been implicated in several physiological processes regulating the activation response of platelets. They are involved in processes leading to granule secretion, integrin activation, platelet aggregation and spreading, and procoagulation. The protein kinase C θ (PKCθ) isoform, which was originally identified in T lymphocytes, is also expressed at relatively high levels in platelets, wherein it is involved in the regulation of hemostasis and thrombosis. Recent studies suggest a role for PKCθ in protease-activated receptor (PAR)-, glycoprotein VI (GPVI) receptor- and glycoprotein α IIbβ 3 integrin receptor-linked signal transduction pathways. The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation.

AB - Members of the protein kinase C (PKC) family of serine/threonine kinases have been implicated in several physiological processes regulating the activation response of platelets. They are involved in processes leading to granule secretion, integrin activation, platelet aggregation and spreading, and procoagulation. The protein kinase C θ (PKCθ) isoform, which was originally identified in T lymphocytes, is also expressed at relatively high levels in platelets, wherein it is involved in the regulation of hemostasis and thrombosis. Recent studies suggest a role for PKCθ in protease-activated receptor (PAR)-, glycoprotein VI (GPVI) receptor- and glycoprotein α IIbβ 3 integrin receptor-linked signal transduction pathways. The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation.

KW - α-Granules

KW - Aggregation

KW - CD62P

KW - Hemostasis

KW - P-selectin

KW - PAR4

KW - Platelets

KW - Protein kinase C θ

KW - Signal transduction

KW - Thrombin

KW - Thrombus formation

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U2 - 10.1016/j.febslet.2011.09.014

DO - 10.1016/j.febslet.2011.09.014

M3 - Review article

C2 - 21944869

AN - SCOPUS:80054059064

SN - 0014-5793

VL - 585

SP - 3208

EP - 3215

JO - FEBS Letters

JF - FEBS Letters

IS - 20

ER -

Protein kinase C-theta in platelet activation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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