Abstract
(Chemical Equation Presented) Triggering leucine: A new ligation strategy of using β-mercaptoleucine coupled with desulfurization at leucine sites was developed, and its applicability in protein synthesis is presented. The efficiency of our Leu-NCL was examined in several model peptides and utilized for the first total synthesis of HIV-1 Tat protein.
Original language | English |
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Pages (from-to) | 1232-1235 |
Number of pages | 4 |
Journal | ChemBioChem |
Volume | 11 |
Issue number | 9 |
DOIs | |
State | Published - 14 Jun 2010 |
Keywords
- Desulfurization
- Leucine
- Native chemical ligation
- Peptides
- Protein synthesis
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry