Abstract
(Chemical Equation Presented) Triggering leucine: A new ligation strategy of using β-mercaptoleucine coupled with desulfurization at leucine sites was developed, and its applicability in protein synthesis is presented. The efficiency of our Leu-NCL was examined in several model peptides and utilized for the first total synthesis of HIV-1 Tat protein.
| Original language | English |
|---|---|
| Pages (from-to) | 1232-1235 |
| Number of pages | 4 |
| Journal | ChemBioChem |
| Volume | 11 |
| Issue number | 9 |
| DOIs | |
| State | Published - 14 Jun 2010 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Desulfurization
- Leucine
- Native chemical ligation
- Peptides
- Protein synthesis
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry
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