Proteins: Coexistence of stability and flexibility

Shlomi Reuveni; Rony Granek; Joseph Klafter

doi:10.4108/ICST.VALUETOOLS2008.4241

Proteins: Coexistence of stability and flexibility

Shlomi Reuveni, Rony Granek, Joseph Klafter

Department of Biotechnology Engineering

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Abstract

We introduce an equation for protein native topology based on recent analysis of data from the Protein Data Bank and on a generalization of the Landau-Peierls instability criterion for fractals. The equation relates the protein fractal dimension d_f, the spectral dimension d_s, and the number of amino acids N. Deviations from the equation may render a protein unfolded. The fractal nature of proteins is shown to bridge their seemingly conflicting properties of stability and flexibility. Over 500 proteins have been analyzed (d_f, d_s, and N) and found to obey this equation of state.

Original language	English
DOIs	https://doi.org/10.4108/ICST.VALUETOOLS2008.4241
State	Published - 1 Jan 2008
Event	3rd International Conference on Performance Evaluation Methodologies and Tools, VALUETOOLS 2008 - Athens, Greece Duration: 20 Oct 2008 → 24 Oct 2008

Conference

Conference	3rd International Conference on Performance Evaluation Methodologies and Tools, VALUETOOLS 2008
Country/Territory	Greece
City	Athens
Period	20/10/08 → 24/10/08

ASJC Scopus subject areas

Instrumentation

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10.4108/ICST.VALUETOOLS2008.4241

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AB - We introduce an equation for protein native topology based on recent analysis of data from the Protein Data Bank and on a generalization of the Landau-Peierls instability criterion for fractals. The equation relates the protein fractal dimension df, the spectral dimension ds, and the number of amino acids N. Deviations from the equation may render a protein unfolded. The fractal nature of proteins is shown to bridge their seemingly conflicting properties of stability and flexibility. Over 500 proteins have been analyzed (df, ds, and N) and found to obey this equation of state.

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ER -

Proteins: Coexistence of stability and flexibility

Abstract

Conference

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