Proteins through the eyes of an organic chemist

Shaswati Mandal; Ashraf Brik

doi:10.1016/j.tet.2022.133022

Proteins through the eyes of an organic chemist

Shaswati Mandal, Ashraf Brik

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Over the past few decades, the advancements in the field of chemical protein synthesis have enabled researchers from both chemistry and biology to address a wide range of biological questions. Utilizing the available chemical toolbox for synthesizing proteins, unique modifications can be introduced to the proteins, which are extremely difficult or impossible to achieve via the current molecular biology methods. We discuss the challenges in chemical protein synthesis and the ways to overcome them. We provide key chemoselective ligation methods and strategies for successful protein synthesis, along with examples of the added value of protein synthesis to advance our understanding of the function of proteins.

Original language	English
Article number	133022
Journal	Tetrahedron
Volume	124
DOIs	https://doi.org/10.1016/j.tet.2022.133022
State	Published - 8 Oct 2022
Externally published	Yes

Keywords

Chemical protein synthesis
Ligations
Post-translation modifications
Probes
Proteins

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2022.133022

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title = "Proteins through the eyes of an organic chemist",

abstract = "Over the past few decades, the advancements in the field of chemical protein synthesis have enabled researchers from both chemistry and biology to address a wide range of biological questions. Utilizing the available chemical toolbox for synthesizing proteins, unique modifications can be introduced to the proteins, which are extremely difficult or impossible to achieve via the current molecular biology methods. We discuss the challenges in chemical protein synthesis and the ways to overcome them. We provide key chemoselective ligation methods and strategies for successful protein synthesis, along with examples of the added value of protein synthesis to advance our understanding of the function of proteins.",

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AU - Brik, Ashraf

PY - 2022/10/8

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AB - Over the past few decades, the advancements in the field of chemical protein synthesis have enabled researchers from both chemistry and biology to address a wide range of biological questions. Utilizing the available chemical toolbox for synthesizing proteins, unique modifications can be introduced to the proteins, which are extremely difficult or impossible to achieve via the current molecular biology methods. We discuss the challenges in chemical protein synthesis and the ways to overcome them. We provide key chemoselective ligation methods and strategies for successful protein synthesis, along with examples of the added value of protein synthesis to advance our understanding of the function of proteins.

KW - Chemical protein synthesis

KW - Ligations

KW - Post-translation modifications

KW - Probes

KW - Proteins

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DO - 10.1016/j.tet.2022.133022

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VL - 124

JO - Tetrahedron

JF - Tetrahedron

M1 - 133022

ER -

Proteins through the eyes of an organic chemist

Abstract

Keywords

ASJC Scopus subject areas

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