@article{0c153c083bfb4a319cab7bb9f457cf3d,
title = "Proteome-wide mapping of PQS-interacting proteins in: Pseudomonas aeruginosa",
abstract = "The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.",
author = "Rambabu Dandela and Danielle Mantin and Cravatt, {Benjamin F.} and Josep Rayo and Meijler, {Michael M.}",
note = "Funding Information: The authors would like to thank Dr Y. Baker and Prof. D. Spring (University of Cambridge, UK), Dr R. Mashiach (ADAMA Agricultural Solutions, Israel), Prof. P. Williams (Univ. of Nottingham), Prof. H. Overklee and Dr B. Florea (Leiden University, Netherlands) for helpful suggestions and discussions, and Prof. E. P. Greenberg, Prof. M. G. Surette, Prof. R. W. Hartmann, Prof. P. Williams and Prof. H. E. Blackwell for providing us with bacterial strains. The research was supported by grants from the European Research Council (Starting Grant 240356) and the USA-Israel Binational Science Foundation (Grant #2011360) to MMM and BFC. DRB acknowledges the Israel-India PBC Outstanding Postdoctoral Research Fellowship. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",
year = "2018",
month = jan,
day = "1",
doi = "10.1039/c7sc04287f",
language = "English",
volume = "9",
pages = "2290--2294",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "8",
}