Proteome-wide mapping of PQS-interacting proteins in: Pseudomonas aeruginosa

Rambabu Dandela, Danielle Mantin, Benjamin F. Cravatt, Josep Rayo, Michael M. Meijler

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.

Original languageEnglish
Pages (from-to)2290-2294
Number of pages5
JournalChemical Science
Volume9
Issue number8
DOIs
StatePublished - 1 Jan 2018

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