Proteomic Analysis of Non-model Plant Tissues Using Phenol Extraction, Two-Dimensional Electrophoresis, and MALDI Mass Spectrometry

  • Petra Peharec Štefanić
  • , Mario Cindrić
  • , Biljana Balen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Separation of plant proteins by means of electrophoretic techniques is quite challenging since different compounds typical for plant cells can interfere and/or reduce the effectiveness of the protein isolation. This is particularly problematic for two-dimensional electrophoresis (2-DE). Therefore, it is important to optimize protein extraction and to establish a robust protocol for 2-DE and downstream processing, primarily mass spectrometry (MS) analysis. Here we give a detailed protocol for protein extraction using phenol method, 2-DE, and MALDI-MS analysis.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages351-370
Number of pages20
DOIs
StatePublished - 1 Jan 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1815
ISSN (Print)1064-3745

Keywords

  • De novo sequencing
  • Isoelectric focusing
  • MALDI-MS/MS
  • Phenol extraction
  • SDS-PAGE
  • Two-dimensional electrophoresis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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