Proton-Conductive Melanin-Like Fibers through Enzymatic Oxidation of a Self-Assembling Peptide

Samala Murali Mohan Reddy, Eileen Raßlenberg, Sian Sloan-Dennison, Travis Hesketh, Ohad Silberbush, Tell Tuttle, Ewen Smith, Duncan Graham, Karen Faulds, Rein V. Ulijn, Nurit Ashkenasy, Ayala Lampel

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Melanin pigments have various properties that are of technological interest including photo- and radiation protection, rich coloration, and electronic functions. Nevertheless, laboratory-based synthesis of melanin and melanin-like materials with morphologies and chemical structures that are specifically optimized for these applications, is currently not possible. Here, melanin-like materials that are produced by enzymatic oxidation of a supramolecular tripeptide structures that are rich in tyrosine and have a 1D morphology are demonstrated, that are retained during the oxidation process while conducting tracks form through oxidative tyrosine crosslinking. Specifically, a minimalistic self-assembling peptide, Lys–Tyr–Tyr (KYY) with strong propensity to form supramolecular fibers, is utilized. Analysis by Raman spectroscopy shows that the tyrosines are pre-organized inside these fibers and, upon enzymatic oxidation, result in connected catechols. These form 1D conducting tracks along the length of the fiber, which gives rise to a level of internal disorder, but retention of the fiber morphology. This results in highly conductive structures demonstrated to be dominated by proton conduction. This work demonstrates the ability to control oxidation but retain a well-defined fibrous morphology that does not have a known equivalent in biology, and demonstrate exceptional conductivity that is enhanced by enzymatic oxidation.

Original languageEnglish
Article number2003511
JournalAdvanced Materials
Volume32
Issue number46
DOIs
StatePublished - 1 Nov 2020

Keywords

  • melanin
  • peptides
  • proton conduction
  • self-assembly
  • supramolecular materials

ASJC Scopus subject areas

  • Materials Science (all)
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint

Dive into the research topics of 'Proton-Conductive Melanin-Like Fibers through Enzymatic Oxidation of a Self-Assembling Peptide'. Together they form a unique fingerprint.

Cite this