Caffeine Treatment Leads to Enhanced Tumor-Specific Reactivity and to Delayed Tumor Appearance in Models of Carcinogen-Induced Tumor and B16 Melanoma

Hadar Eini; Yair Cohen; Eli C Lewis; Cidio Chaimovitz; Amos Douvdevani

doi:10.1016/j.cyto.2011.07.235

Caffeine Treatment Leads to Enhanced Tumor-Specific Reactivity and to Delayed Tumor Appearance in Models of Carcinogen-Induced Tumor and B16 Melanoma

Hadar Eini, Yair Cohen, Eli C Lewis, Cidio Chaimovitz, Amos Douvdevani

Basic Sciences Divisions

Research output: Contribution to journal › Meeting Abstract

Abstract

Background: Large epidemiological studies show reduced cancer rate in coffee drinking subjects. It was hypothesized that the protective effect of caffeine is related to its antagonist properties on adenosine A2A receptor (A2AR). Adenosine accumulates in solid tumors and has been shown to stimulate angiogenesis and to inhibit the activity of immune cells mainly through A2AR. Here, we examined the effect of caffeine on tumor development and immune surveillance.

Original language	English
Pages (from-to)	84-84
Number of pages	1
Journal	Cytokine
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/j.cyto.2011.07.235
State	Published - Oct 2011

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title = "Caffeine Treatment Leads to Enhanced Tumor-Specific Reactivity and to Delayed Tumor Appearance in Models of Carcinogen-Induced Tumor and B16 Melanoma",

abstract = "Background: Large epidemiological studies show reduced cancer rate in coffee drinking subjects. It was hypothesized that the protective effect of caffeine is related to its antagonist properties on adenosine A2A receptor (A2AR). Adenosine accumulates in solid tumors and has been shown to stimulate angiogenesis and to inhibit the activity of immune cells mainly through A2AR. Here, we examined the effect of caffeine on tumor development and immune surveillance. ",

author = "Hadar Eini and Yair Cohen and Lewis, \{Eli C\} and Cidio Chaimovitz and Amos Douvdevani",

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AU - Eini, Hadar

AU - Cohen, Yair

AU - Lewis, Eli C

AU - Chaimovitz, Cidio

AU - Douvdevani, Amos

PY - 2011/10

Y1 - 2011/10

N2 - Background: Large epidemiological studies show reduced cancer rate in coffee drinking subjects. It was hypothesized that the protective effect of caffeine is related to its antagonist properties on adenosine A2A receptor (A2AR). Adenosine accumulates in solid tumors and has been shown to stimulate angiogenesis and to inhibit the activity of immune cells mainly through A2AR. Here, we examined the effect of caffeine on tumor development and immune surveillance.

AB - Background: Large epidemiological studies show reduced cancer rate in coffee drinking subjects. It was hypothesized that the protective effect of caffeine is related to its antagonist properties on adenosine A2A receptor (A2AR). Adenosine accumulates in solid tumors and has been shown to stimulate angiogenesis and to inhibit the activity of immune cells mainly through A2AR. Here, we examined the effect of caffeine on tumor development and immune surveillance.

U2 - 10.1016/j.cyto.2011.07.235

DO - 10.1016/j.cyto.2011.07.235

M3 - Meeting Abstract

SN - 1043-4666

VL - 56

SP - 84

EP - 84

JO - Cytokine

JF - Cytokine

IS - 1

ER -

Caffeine Treatment Leads to Enhanced Tumor-Specific Reactivity and to Delayed Tumor Appearance in Models of Carcinogen-Induced Tumor and B16 Melanoma

Abstract

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