Caffeine Treatment Leads to Enhanced Tumor-Specific Reactivity and to Delayed Tumor Appearance in Models of Carcinogen-Induced Tumor and B16 Melanoma

Hadar Eini, Yair Cohen, Eli C Lewis, Cidio Chaimovitz, Amos Douvdevani

Research output: Contribution to journalMeeting Abstract

Abstract

Background: Large epidemiological studies show reduced cancer rate in coffee drinking subjects. It was hypothesized that the protective effect of caffeine is related to its antagonist properties on adenosine A2A receptor (A2AR). Adenosine accumulates in solid tumors and has been shown to stimulate angiogenesis and to inhibit the activity of immune cells mainly through A2AR. Here, we examined the effect of caffeine on tumor development and immune surveillance.
Original languageEnglish
Pages (from-to)84-84
Number of pages1
JournalCytokine
Volume56
Issue number1
DOIs
StatePublished - Oct 2011

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