Pseudo-Precocious Puberty in a Male Patient and the Melatonin-Testosterone Relationship

Rafael Luboshitzky; Dov Tiosano; Miriam Ben-Harush; Isaam Thuma; Avraham Ayash; Peretz Lavie; Amos Etzioni

doi:10.1515/JPEM.1995.8.4.295

Pseudo-Precocious Puberty in a Male Patient and the Melatonin-Testosterone Relationship

Rafael Luboshitzky, Dov Tiosano, Miriam Ben-Harush, Isaam Thuma, Avraham Ayash, Peretz Lavie, Amos Etzioni

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We describe a 14 year-old boy with a pineal germ cell tumor which secreted βHCG. Serum testosterone levels were markedly elevated with concomitant decreased LH secretion. 24-h serum melatonin levels were suppressed and lacked the normal nocturnal rise. Pineal radiation therapy was followed by tumor regression and the diminution of βHCG stimulated testosterone, which in turn inhibited melatonin and LH. When βHCG and testosterone were normalized after tumor radiation, a recovery of normal melatonin and LH secretory pattern occurred. These results indicate that circulating testosterone down-regulates pineal melatonin.

Original language	English
Pages (from-to)	295-300
Number of pages	6
Journal	Journal of Pediatric Endocrinology and Metabolism
Volume	8
Issue number	4
DOIs	https://doi.org/10.1515/JPEM.1995.8.4.295
State	Published - 1 Jan 1995
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1515/JPEM.1995.8.4.295

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title = "Pseudo-Precocious Puberty in a Male Patient and the Melatonin-Testosterone Relationship",

abstract = "We describe a 14 year-old boy with a pineal germ cell tumor which secreted βHCG. Serum testosterone levels were markedly elevated with concomitant decreased LH secretion. 24-h serum melatonin levels were suppressed and lacked the normal nocturnal rise. Pineal radiation therapy was followed by tumor regression and the diminution of βHCG stimulated testosterone, which in turn inhibited melatonin and LH. When βHCG and testosterone were normalized after tumor radiation, a recovery of normal melatonin and LH secretory pattern occurred. These results indicate that circulating testosterone down-regulates pineal melatonin.",

author = "Rafael Luboshitzky and Dov Tiosano and Miriam Ben-Harush and Isaam Thuma and Avraham Ayash and Peretz Lavie and Amos Etzioni",

note = "Funding Information: We would like to thank Mrs. Frances Nachrnani for typing this manuscript and Ms Zmira Staler for her technical assistance. This study was supported by grants from the B. Rappaport Research Fund and the Israeli Ministry of Health (181-466).",

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AU - Tiosano, Dov

AU - Ben-Harush, Miriam

AU - Thuma, Isaam

AU - Ayash, Avraham

AU - Lavie, Peretz

AU - Etzioni, Amos

N1 - Funding Information: We would like to thank Mrs. Frances Nachrnani for typing this manuscript and Ms Zmira Staler for her technical assistance. This study was supported by grants from the B. Rappaport Research Fund and the Israeli Ministry of Health (181-466).

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N2 - We describe a 14 year-old boy with a pineal germ cell tumor which secreted βHCG. Serum testosterone levels were markedly elevated with concomitant decreased LH secretion. 24-h serum melatonin levels were suppressed and lacked the normal nocturnal rise. Pineal radiation therapy was followed by tumor regression and the diminution of βHCG stimulated testosterone, which in turn inhibited melatonin and LH. When βHCG and testosterone were normalized after tumor radiation, a recovery of normal melatonin and LH secretory pattern occurred. These results indicate that circulating testosterone down-regulates pineal melatonin.

AB - We describe a 14 year-old boy with a pineal germ cell tumor which secreted βHCG. Serum testosterone levels were markedly elevated with concomitant decreased LH secretion. 24-h serum melatonin levels were suppressed and lacked the normal nocturnal rise. Pineal radiation therapy was followed by tumor regression and the diminution of βHCG stimulated testosterone, which in turn inhibited melatonin and LH. When βHCG and testosterone were normalized after tumor radiation, a recovery of normal melatonin and LH secretory pattern occurred. These results indicate that circulating testosterone down-regulates pineal melatonin.

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Pseudo-Precocious Puberty in a Male Patient and the Melatonin-Testosterone Relationship

Abstract

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