Psoriasis and dyslipidaemia: A population-based study

Jacob Dreiher, Dahlia Weitzman, Batya Davidovici, Jonathan Shapiro, Arnon D. Cohen

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Previous reports demonstrated an association between psoriasis and the metabolic syndrome. The aim of this study was to elucidate the association between psoriasis and dyslipidaemia. A cross-sectional study was performed utilizing a population-based database. Psoriasis patients were compared with enrollees without psoriasis regarding the prevalence of dyslipidaemia and lipid levels. Comparison of lipid levels was performed on a "low-risk" subset of subjects without diabetes, hypertension and cardiovascular disease. The study included 10,669 psoriasis patients and 22,996 subjects without psoriasis. The prevalence of dyslipidaemia was significantly higher in psoriasis patients (odds ratio (OR)=1.48, 95% confidence interval (CI) 1.40-1.55). The association remained significant after controlling for confounders (OR=1.19, 95% CI 1.12-1.26, p<0.001). In multivariate analysis of the "low-risk" subset, triglyceride levels were higher in psoriasis patients and high-density lipoprotein cholesterol levels were lower. This study supports previous reports of an association between psoriasis and lipid abnormalities.

Original languageEnglish
Pages (from-to)561-565
Number of pages5
JournalActa Dermato-Venereologica
Volume88
Issue number6
DOIs
StatePublished - 1 Dec 2008

Keywords

  • Cholesterol
  • Dyslipidaemia
  • Hyperlipidaemia
  • Lipid levels
  • Metabolic syndrome
  • Psoriasis
  • Triglycerides

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