Psoriasis and hidradenitis suppurativa: A large-scale population-based study

Khalaf Kridin, Michal Shani, Yochai Schonmann, Shani Fisher, Guy Shalom, Doron Comaneshter, Erez Batat, Arnon D. Cohen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background: The coexistence of psoriasis and hidradenitis suppurativa (HS) has been described, but the association between these conditions is yet to be firmly established. Objective: To study the association between psoriasis and HS by using a large-scale real-life computerized database. Methods: A cross-sectional study was conducted to compare the prevalence of HS among patients with psoriasis with that among age-, sex- and ethnicity-matched control subjects. Results: A total of 68,836 patients with psoriasis and 68,836 controls were included in the study. The prevalence of HS was increased in patients with psoriasis versus in those in the control group (0.3% vs 0.2%, respectively; odds ratio, 1.8; 95% confidence interval, 1.5-2.3; P < .001). In a multivariate analysis adjusting for smoking, obesity, and other comorbidities, psoriasis was still associated with HS (odds ratio, 1.8; 95% confidence interval, 1.4-2.2; P < .001). Patients with coexistent psoriasis and HS were significantly younger (39.0 ± 15.7 vs 42.6 ± 21.2 years [P = .015]) and had a higher prevalence of obesity (35.1% vs 25.3% [P = .001]) and smoking (58.5% vs 37.3% [P < .001]) compared with patients with psoriasis alone. Limitations: Retrospective data collection. Conclusions: A positive association was observed between HS and psoriasis. Further longitudinal observational studies are necessary to establish these findings in other study populations.

Original languageEnglish
Pages (from-to)e231-e236
JournalJournal of the American Academy of Dermatology
Volume88
Issue number5
DOIs
StatePublished - 1 May 2023

Keywords

  • association
  • comorbidities
  • hidradenitis suppurativa
  • large-scale
  • population-based
  • psoriasis

ASJC Scopus subject areas

  • Dermatology

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