TY - JOUR
T1 - Psoriasis and hidradenitis suppurativa
T2 - A large-scale population-based study
AU - Kridin, Khalaf
AU - Shani, Michal
AU - Schonmann, Yochai
AU - Fisher, Shani
AU - Shalom, Guy
AU - Comaneshter, Doron
AU - Batat, Erez
AU - Cohen, Arnon D.
N1 - Funding Information:
Funding sources: None.
Publisher Copyright:
© 2018
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Background: The coexistence of psoriasis and hidradenitis suppurativa (HS) has been described, but the association between these conditions is yet to be firmly established. Objective: To study the association between psoriasis and HS by using a large-scale real-life computerized database. Methods: A cross-sectional study was conducted to compare the prevalence of HS among patients with psoriasis with that among age-, sex- and ethnicity-matched control subjects. Results: A total of 68,836 patients with psoriasis and 68,836 controls were included in the study. The prevalence of HS was increased in patients with psoriasis versus in those in the control group (0.3% vs 0.2%, respectively; odds ratio, 1.8; 95% confidence interval, 1.5-2.3; P < .001). In a multivariate analysis adjusting for smoking, obesity, and other comorbidities, psoriasis was still associated with HS (odds ratio, 1.8; 95% confidence interval, 1.4-2.2; P < .001). Patients with coexistent psoriasis and HS were significantly younger (39.0 ± 15.7 vs 42.6 ± 21.2 years [P = .015]) and had a higher prevalence of obesity (35.1% vs 25.3% [P = .001]) and smoking (58.5% vs 37.3% [P < .001]) compared with patients with psoriasis alone. Limitations: Retrospective data collection. Conclusions: A positive association was observed between HS and psoriasis. Further longitudinal observational studies are necessary to establish these findings in other study populations.
AB - Background: The coexistence of psoriasis and hidradenitis suppurativa (HS) has been described, but the association between these conditions is yet to be firmly established. Objective: To study the association between psoriasis and HS by using a large-scale real-life computerized database. Methods: A cross-sectional study was conducted to compare the prevalence of HS among patients with psoriasis with that among age-, sex- and ethnicity-matched control subjects. Results: A total of 68,836 patients with psoriasis and 68,836 controls were included in the study. The prevalence of HS was increased in patients with psoriasis versus in those in the control group (0.3% vs 0.2%, respectively; odds ratio, 1.8; 95% confidence interval, 1.5-2.3; P < .001). In a multivariate analysis adjusting for smoking, obesity, and other comorbidities, psoriasis was still associated with HS (odds ratio, 1.8; 95% confidence interval, 1.4-2.2; P < .001). Patients with coexistent psoriasis and HS were significantly younger (39.0 ± 15.7 vs 42.6 ± 21.2 years [P = .015]) and had a higher prevalence of obesity (35.1% vs 25.3% [P = .001]) and smoking (58.5% vs 37.3% [P < .001]) compared with patients with psoriasis alone. Limitations: Retrospective data collection. Conclusions: A positive association was observed between HS and psoriasis. Further longitudinal observational studies are necessary to establish these findings in other study populations.
KW - association
KW - comorbidities
KW - hidradenitis suppurativa
KW - large-scale
KW - population-based
KW - psoriasis
UR - http://www.scopus.com/inward/record.url?scp=85152403386&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2018.11.036
DO - 10.1016/j.jaad.2018.11.036
M3 - Article
C2 - 30502412
AN - SCOPUS:85152403386
SN - 0190-9622
VL - 88
SP - e231-e236
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5
ER -