Psychiatric illness and adverse pregnancy outcome

Naomi Schneid-Kofman, Eyal Sheiner, Amalia Levy

    Research output: Contribution to journalArticlepeer-review

    48 Scopus citations


    Objectives: To identify the adverse effect of psychiatric illness during pregnancy on pregnancy outcome. Methods: A large population-based study of deliveries (1988-2005) was conducted that compared women with and without psychiatric illness. Stratified analysis included multiple logistic regression models. Results: Out of 181,479 deliveries, 607 (0.3%) women reported psychiatric illness: depressive and anxiety disorders (39%), schizophrenia (11%), or other psychiatric illness (50%). The psychiatric patients were significantly older, with higher prevalence of diabetes and hypertensive disorders. Perinatal mortality rate, congenital malformations, low Apgar scores, and low birth weight (< 2500 g) were significantly increased. Multivariable logistic regression models determined that psychiatric illness during pregnancy is an independent risk factor for perinatal mortality (odds ratio [OR] 2.4; 95% CI, 1.5-3.7, P < 0.001) and congenital malformations (OR 1.4; 95% CI, 1.01-1.9, P = 0.03). Conclusions: Psychiatric illness is an independent risk factor for congenital malformations and perinatal mortality, and prenatal care should be adjusted accordingly.

    Original languageEnglish
    Pages (from-to)53-56
    Number of pages4
    JournalInternational Journal of Gynecology and Obstetrics
    Issue number1
    StatePublished - 1 Jan 2008


    • Fetal malformations
    • Perinatal mortality
    • Psychiatric illness
    • Risk factors

    ASJC Scopus subject areas

    • Obstetrics and Gynecology


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