Psychological Distress in Patients with Crohn's Disease: A Cross-Sectional Study Using the Brief Symptom Inventory Instrument

Shmuel Odes, Vered Slonim-Nevo, Ruslan Sergienko, Michael Friger, Doron Schwartz, Dan Greenberg, Orly Sarid

Research output: Contribution to journalMeeting Abstractpeer-review


BACKGROUND: Crohn’s disease (CD) patients all experience psychological distress, but its characteristics are incompletely understood. We report an in-depth cross-sectional study in 297 patients. METHODS: The Brief Symptom Inventory (BSI, Derogatis 1983) measures psychological distress: 59 items assess depression, somatization, obsession-compulsive, interpersonal sensitivity, anxiety, hostility, phobic anxiety, paranoid ideation and psychoticism. BSI
summary scores are: General Severity Index (GSI, mean of category scores, range 0-4), Positive Symptom Total (PST, sum of recorded symptoms) and Positive Symptom Distress Index (PSDI, summated item values divided by PST); higher
scores imply more distress. Patients completed demographics, Patient-Harvey-Bradshaw Index (P-HBI), BSI, Family Assessment Device (FAD, measures family functioning) and Multidimensional Scale of Perceived Social Support (MSPSS, measures social support). RESULTS: GSI scores were similarly elevated in men 1.0+8.7 and women.0+8.8, but significantly higher in single 1.2+8 vs coupled
.9+.8, smokers 1.3+.8 vs non-smokers .9+.8 and nonworking 1.2+.9 vs working .9+.7. PST scores were: men 25.8+15.2 vs women 26.4+13.7 (ns), single 29.614.0 vs coupled 23.1+14.0, smokers 30.3+14.0 vs non-smokers
25.0+14.4 and non-working 29.3+14.6 vs working 24.4+18.8. PSDI scores were: men 1.8+1.7 vs women 1.8+1.7 (ns), single 1.9+.6 vs coupled 1.7+.6, smokers 2.0.6 vs non-smokers 1.7+.6, and non-working 1.9.7 vs working 1.7.6. GSI, PST and PSDI scores correlated significantly with age, economic status, P-HBI, FAD and MSPSS (Table 1). Multivariate regression analysis identified age, economic status, FAD, MSPSS, P-HBI as predictors of distress (Table 2). Notably, gender did not predict distress.
CONCLUSION: Psychological distress is increased in CD and predicted by age, economic status, family relationship, social support and disease activity. Caregivers should incorporate these findings in patient management.
Original languageEnglish GB
Pages (from-to)S49-S49
Issue number1
StatePublished - Jan 2018


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