Purinergic stimulation of ciliary activity

Alex Braiman; Shai D. Silberberg; Zvi Priel

doi:10.1002/1098-2299(200007/08)50:3/4<550::AID-DDR38>3.0.CO;2-X

Purinergic stimulation of ciliary activity

Alex Braiman, Shai D. Silberberg, Zvi Priel

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

The mucociliary system is responsible for maintaining the airways clean of inhaled particles and pathogens. This task is performed by ciliated cells that transport the mucus from the lungs to the upper airways. The energy transferred by the cilium to the mucus blanket is proportional to the square of the ciliary beat frequency (CBF), hence CBF has a profound effect on the efficiency of mucociliary clearance and impairment of ciliary activity may lead to severe pathological conditions by jeopardizing mucociliary clearance. Extracellular ATP is one of the most potent activators of ciliary beating. It acts through purinergic receptors located on the cell surface. Ciliary stimulation is achieved by means of elevation in intracellular calcium concentration and activation of protein kinases. This article outlines the mechanism of purinergic ciliary stimulation revealed to date. (C) 2000 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	550-554
Number of pages	5
Journal	Drug Development Research
Volume	50
Issue number	3-4
DOIs	https://doi.org/10.1002/1098-2299(200007/08)50:3/4<550::AID-DDR38>3.0.CO;2-X
State	Published - 1 Jan 2000

Keywords

Calcium influx
Calmodulin
Cilia
NO-pathway
P2X
P2Y
PLC

ASJC Scopus subject areas

Drug Discovery

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10.1002/1098-2299(200007/08)50:3/4<550::AID-DDR38>3.0.CO;2-X

Cite this

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title = "Purinergic stimulation of ciliary activity",

abstract = "The mucociliary system is responsible for maintaining the airways clean of inhaled particles and pathogens. This task is performed by ciliated cells that transport the mucus from the lungs to the upper airways. The energy transferred by the cilium to the mucus blanket is proportional to the square of the ciliary beat frequency (CBF), hence CBF has a profound effect on the efficiency of mucociliary clearance and impairment of ciliary activity may lead to severe pathological conditions by jeopardizing mucociliary clearance. Extracellular ATP is one of the most potent activators of ciliary beating. It acts through purinergic receptors located on the cell surface. Ciliary stimulation is achieved by means of elevation in intracellular calcium concentration and activation of protein kinases. This article outlines the mechanism of purinergic ciliary stimulation revealed to date. (C) 2000 Wiley-Liss, Inc.",

keywords = "Calcium influx, Calmodulin, Cilia, NO-pathway, P2X, P2Y, PLC",

author = "Alex Braiman and Silberberg, {Shai D.} and Zvi Priel",

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AU - Braiman, Alex

AU - Silberberg, Shai D.

AU - Priel, Zvi

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N2 - The mucociliary system is responsible for maintaining the airways clean of inhaled particles and pathogens. This task is performed by ciliated cells that transport the mucus from the lungs to the upper airways. The energy transferred by the cilium to the mucus blanket is proportional to the square of the ciliary beat frequency (CBF), hence CBF has a profound effect on the efficiency of mucociliary clearance and impairment of ciliary activity may lead to severe pathological conditions by jeopardizing mucociliary clearance. Extracellular ATP is one of the most potent activators of ciliary beating. It acts through purinergic receptors located on the cell surface. Ciliary stimulation is achieved by means of elevation in intracellular calcium concentration and activation of protein kinases. This article outlines the mechanism of purinergic ciliary stimulation revealed to date. (C) 2000 Wiley-Liss, Inc.

AB - The mucociliary system is responsible for maintaining the airways clean of inhaled particles and pathogens. This task is performed by ciliated cells that transport the mucus from the lungs to the upper airways. The energy transferred by the cilium to the mucus blanket is proportional to the square of the ciliary beat frequency (CBF), hence CBF has a profound effect on the efficiency of mucociliary clearance and impairment of ciliary activity may lead to severe pathological conditions by jeopardizing mucociliary clearance. Extracellular ATP is one of the most potent activators of ciliary beating. It acts through purinergic receptors located on the cell surface. Ciliary stimulation is achieved by means of elevation in intracellular calcium concentration and activation of protein kinases. This article outlines the mechanism of purinergic ciliary stimulation revealed to date. (C) 2000 Wiley-Liss, Inc.

KW - Calcium influx

KW - Calmodulin

KW - Cilia

KW - NO-pathway

KW - P2X

KW - P2Y

KW - PLC

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JF - Drug Development Research

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ER -

Purinergic stimulation of ciliary activity

Abstract

Keywords

ASJC Scopus subject areas

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