PVP-coated Gd-grafted nanodiamonds as a novel and potentially safer contrast agent for in vivo MRI

Alexander M. Panich, Moti Salti, Ofer Prager, Evyatar Swissa, Yuri V. Kulvelis, Elena B. Yudina, Alexander E. Aleksenskii, Shaul D. Goren, Alexander Ya Vul', Alexander I. Shames

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose: Testing the potential use of saline suspension of polyvinylpyrrolidone (PVP)-coated gadolinium(Gd)-grafted detonation nanodiamonds (DND) as a novel contrast agent in MRI. Methods: Stable saline suspensions of highly purified de-agglomerated Gd-grafted DND particles coated by a PVP protective shell were prepared. T1 and T2 proton relaxivities of the suspensions with varying gadolinium concentration were measured at 8 Tesla. A series of ex vivo (phantom) and in vivo dynamic scans were obtained in 3 Tesla MRI using PVP-coated Gd-grafted DND and gadoterate meglumin in equal concentrations of gadolinium, and then T1-weighted hyperintensity was compared. Results: The proton relaxivities of PVP-coated Gd-grafted DND were found to be r1 = 15.9 ± 0.8 s−1 mM−1 and r2 = 262 ± 15 s−1 mM−1, respectively, which are somewhat less than those for uncoated Gd-grafted DND but still high enough. Ex vivo MRI evaluation of PVP-coated Gd-grafted DND results with a dose-dependent T1-weighted hyperintensity with a significant advantage over the same for gadoterate meglumin. The same was found when the 2 contrast agents were tested in vivo. Conclusion: The novel MRI contrast agent — saline suspensions of PVP-coated Gd-grafted DND — provides significantly higher signal intensities than the common tracer gadoterate meglumin, therefore increasing its potential for a safer use in clinics.

Original languageEnglish
Pages (from-to)935-942
Number of pages8
JournalMagnetic Resonance in Medicine
Volume86
Issue number2
DOIs
StatePublished - 1 Aug 2021

Keywords

  • MRI contrast agent
  • detonation nanodiamond
  • gadolinium
  • relaxivity

Fingerprint

Dive into the research topics of 'PVP-coated Gd-grafted nanodiamonds as a novel and potentially safer contrast agent for in vivo MRI'. Together they form a unique fingerprint.

Cite this