Quality of life, coping and depression in systemic lupus erythematosus

Mahmoud Abu-Shakra

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Physical, mental and social well-being are important outcomes in patients with chronic rheumatic diseases, including systemic lupus erythematosus (SLE). The MOS SF-36 and the WHO QoL Bref are appropriate for assessing quality of life (QoL) in patients with SLE. The QoL of patients with SLE is impaired compared with that of controls. Fibromyalgia adversely affects the QoL of SLE patients. Women with SLE had significantly lower scores on subscales of the sense of coherence (SoC) compared with matched controls. This reduced SoC in SLE women represents impaired adaptive coping and is independently associated with reduced QoL in women with SLE. Depression and anxiety are common among SLE patients, and the frequency is similar to that in patients with rheumatoid arthritis. A reciprocal longitudinal relationship between depression and illness intrusiveness was found in patients with SLE. Disease activity and damage are not associated with depression. The subjective experience, not the illness per se, causes depression.

Original languageEnglish
Pages (from-to)144-145
Number of pages2
JournalIsrael Medical Association Journal
Issue number3-4
StatePublished - 1 Mar 2016
Externally publishedYes


  • Quality of life (QoL)
  • Sense of coherence (SoC)
  • Systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • Medicine (all)


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