TY - JOUR
T1 - Quorum sensing in Vibrio harveyi
T2 - Probing the specificity of the LuxP binding site
AU - Lowery, Colin A.
AU - McKenzie, Kathleen M.
AU - Qi, Longwu
AU - Meijler, Michael M.
AU - Janda, Kim D.
N1 - Funding Information:
We gratefully acknowledge Dr. Masayuki Matsushita for his help with computational evaluation of ligand–receptor interactions, and The Skaggs Institute for Chemical Biology, as well as National Institute of Health grants AI-055781 and AI-055778, for financial support. We also thank Professor Bonnie Bassler for providing us with Vibrio harveyi strains BB170 and MM30.
PY - 2005/5/2
Y1 - 2005/5/2
N2 - Quorum sensing activity was investigated in the bacterium Vibrio harveyi using a series of both natural and nonnatural analogs of DPD, the penultimate precursor to autoinducer AI-2. The progression of molecules that were both synthesized and investigated includes enantiomeric variants, carbon-chain extension, and hydroxyl-functional group addition/deletions of DPD. The compilation of these studies reveals a binding cleft that can accommodate a number of different structural variants of DPD, albeit with invariably lower activities.
AB - Quorum sensing activity was investigated in the bacterium Vibrio harveyi using a series of both natural and nonnatural analogs of DPD, the penultimate precursor to autoinducer AI-2. The progression of molecules that were both synthesized and investigated includes enantiomeric variants, carbon-chain extension, and hydroxyl-functional group addition/deletions of DPD. The compilation of these studies reveals a binding cleft that can accommodate a number of different structural variants of DPD, albeit with invariably lower activities.
KW - Bacterial communication
KW - Quorum sensing
KW - Quorum sensing analogs
UR - http://www.scopus.com/inward/record.url?scp=17144420544&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2005.02.069
DO - 10.1016/j.bmcl.2005.02.069
M3 - Article
AN - SCOPUS:17144420544
SN - 0960-894X
VL - 15
SP - 2395
EP - 2398
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 9
ER -