Radiation therapy and immunotherapy— A potential combination in cancer treatment

N. Asna, A. Livoff, Ron Batash, R. Debbi, P. Schaffer, T. Rivkind, M. Schaffer

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Background Radiation therapy (rt) is a longstanding treatment modality for cancer. In addition, immune checkpoint blockade has been a significant development in the field of immunotherapy, modifying key immunosuppressive pathways of cancer cells. Methods The aim of the present work was to review current concepts of rt and immunotherapy synergism, the abscopal effect, and the molecular effects of rt in the tumour microenvironment, its influence on immune stimulation, and potential clinical outcomes that might evolve from ongoing studies. We also discuss potential predictors of clinical response. Results Up-to-date literature concerning the mechanisms, interactions, and latest knowledge about rt and immunotherapy was reviewed and summarized, and is presented here. Conclusions The possibility of using hyperfractionated rt to combine an abscopal effect with the enhanced effect of immune treatment using checkpoint blockade is a very promising method for future tumour treatments.

Original languageEnglish
Pages (from-to)e454-e460
JournalCurrent Oncology
Volume25
Issue number5
DOIs
StatePublished - 1 Oct 2018

Keywords

  • Abscopal effect
  • Checkpoint blockade
  • Combination therapy
  • Immunotherapy
  • PD-L1
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology

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