Radiographic overlap of recurrent Caffey disease and chronic recurrent multifocal osteomyelitis (CRMO) with considerations of molecular origins

Teresa Chapman, Sarah J. Menashe, Benjamin H. Taragin

Research output: Contribution to journalReview articlepeer-review

Abstract

Caffey disease, or infantile cortical hyperostosis, classically describes a self-limited inflammatory disorder that presents in the infant with fussiness, focal swelling and sometimes fever. Imaging is conventionally limited to radiography, which shows mild to profound subperiosteal bone formation and sometimes deformity. This disease was not uncommonly diagnosed in the late 20th century. Interestingly, the disease may not just occur in the infant, and it may be due to a genetic mutation in the alpha-one chain of type 1 collagen (COL1A1). Recurrent or delayed onset in the older child or adolescent also occurs. In more recent years, another type of inflammatory bone disorder, chronic sterile osteomyelitis, has been frequently recognized and, depending on the radiographic stage or the diagnostic modality used, may have characteristics overlapping with Caffey disease. In this review, we discuss the demographics, imaging and known etiologies for Caffey disease and chronic recurrent multifocal osteomyelitis and raise the possibility of similar molecular origins.

Original languageEnglish
Pages (from-to)618-627
Number of pages10
JournalPediatric Radiology
Volume50
Issue number5
DOIs
StatePublished - 1 May 2020
Externally publishedYes

Keywords

  • COL1A1
  • Caffey disease
  • Children
  • Chronic recurrent multifocal osteomyelitis
  • Infantile cortical hyperostosis
  • Radiography
  • Sclerosing bone disease
  • Sterile osteomyelitis

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