Radioiodine Uptake in Incidentally Detected Neuroendocrine Tumor: Correlative Imaging with FDG PET/CT and 68Ga-DOTATATE PET/CT

Nir Hod; Sophie Lantsberg; Daniel Levin

doi:10.1097/RLU.0000000000004254

Radioiodine Uptake in Incidentally Detected Neuroendocrine Tumor: Correlative Imaging with FDG PET/CT and ⁶⁸Ga-DOTATATE PET/CT

Nir Hod
, Sophie Lantsberg
, Daniel Levin

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Radioiodine whole-body scintigraphy has long been used for detection of differentiated thyroid carcinoma with high avidity in functioning thyroid tissues. However, uptake is not completely specific, and "false-positive"uptake in nonthyroidal tumors have rarely been reported. Herein, we present a case of incidentally detected neuroendocrine tumor showing high radioiodine uptake initially suspected to be thyroid metastasis. Correlative imaging with FDG PET/CT and 68Ga-DOTATATE PET/CT is presented, and literature survey is discussed. We conclude that neuroendocrine tumor should be added to the reported list of neoplasms that can show "false-positive"uptake representing a potential interpretative pitfall.

Original language	English
Pages (from-to)	E643-E646
Journal	Clinical Nuclear Medicine
Volume	47
Issue number	10
DOIs	https://doi.org/10.1097/RLU.0000000000004254
State	Published - 1 Oct 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

FDG PET/CT
Ga-DOTATATE PET/CT
differentiated thyroid carcinoma
false-positive uptake
neuroendocrine tumor
radioiodine I whole-body scintigraphy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000004254

Cite this

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title = "Radioiodine Uptake in Incidentally Detected Neuroendocrine Tumor: Correlative Imaging with FDG PET/CT and 68Ga-DOTATATE PET/CT",

abstract = "Radioiodine whole-body scintigraphy has long been used for detection of differentiated thyroid carcinoma with high avidity in functioning thyroid tissues. However, uptake is not completely specific, and {"}false-positive{"}uptake in nonthyroidal tumors have rarely been reported. Herein, we present a case of incidentally detected neuroendocrine tumor showing high radioiodine uptake initially suspected to be thyroid metastasis. Correlative imaging with FDG PET/CT and 68Ga-DOTATATE PET/CT is presented, and literature survey is discussed. We conclude that neuroendocrine tumor should be added to the reported list of neoplasms that can show {"}false-positive{"}uptake representing a potential interpretative pitfall.",

keywords = "FDG PET/CT, Ga-DOTATATE PET/CT, differentiated thyroid carcinoma, false-positive uptake, neuroendocrine tumor, radioiodine I whole-body scintigraphy",

author = "Nir Hod and Sophie Lantsberg and Daniel Levin",

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AU - Lantsberg, Sophie

AU - Levin, Daniel

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AB - Radioiodine whole-body scintigraphy has long been used for detection of differentiated thyroid carcinoma with high avidity in functioning thyroid tissues. However, uptake is not completely specific, and "false-positive"uptake in nonthyroidal tumors have rarely been reported. Herein, we present a case of incidentally detected neuroendocrine tumor showing high radioiodine uptake initially suspected to be thyroid metastasis. Correlative imaging with FDG PET/CT and 68Ga-DOTATATE PET/CT is presented, and literature survey is discussed. We conclude that neuroendocrine tumor should be added to the reported list of neoplasms that can show "false-positive"uptake representing a potential interpretative pitfall.

KW - FDG PET/CT

KW - Ga-DOTATATE PET/CT

KW - differentiated thyroid carcinoma

KW - false-positive uptake

KW - neuroendocrine tumor

KW - radioiodine I whole-body scintigraphy

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