Abstract
Click and go: By using click chemistry based on a new triazole forming reaction condition (see scheme), over 100 triazole compounds generated in microtiter plates from a core structure were screened for HIV protease inhibition in situ without product isolation. Potent inhibitors, active at nanomolar concentrations, against the wild type and drug resistant mutants were identified.
| Original language | English |
|---|---|
| Pages (from-to) | 1246-1248 |
| Number of pages | 3 |
| Journal | ChemBioChem |
| Volume | 4 |
| Issue number | 11 |
| DOIs | |
| State | Published - 7 Nov 2003 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Click chemistry
- Enzyme
- HIV protease
- Inhibitors
- Screening
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry
Fingerprint
Dive into the research topics of 'Rapid Diversity-Oriented Synthesis in Microtiter Plates for in Situ Screening of HIV Protease Inhibitors'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver