Rapid lithiumization in acute manic patients

D. G. Moscovich, B. Shapira, B. Lerer, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Nine patients with acute mania were treated with high‐dose lithium therapy and daily blood level monitoring for the first 3 days of treatment. Rapid reduction in psychopathology was seen. It is possible that the delay of 7–10 days in clinical response to usual lithium treatment may be partially pharmacokinetic, and that high‐dose lithium loading at the onset of treatment of mania may reduce the need for neuroleptic co‐treatment.

Original languageEnglish
Pages (from-to)343-345
Number of pages3
JournalHuman Psychopharmacology
Issue number5
StatePublished - 1 Jan 1992
Externally publishedYes


  • Lithium
  • high‐dose
  • mania

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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