Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities

Shimrit Ohayon, Maya Refua, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Studying and targeting deubiquitinases is of high importance due to their various roles in cellular processes and involvement in diseases such as cancer. The recent development of unique probes and reagents using chemical synthesis of proteins became very instrumental in supporting these efforts. Here, we present a protein synthetic approach that enables the rapid synthesis of differently modified labeled-ubiquitinated peptides to facilitate rapid optimization of deubiquitinase substrates.

Original languageEnglish
Pages (from-to)8182-8186
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number30
DOIs
StatePublished - 14 Aug 2015
Externally publishedYes

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