Rat brain monoamines after acute and chronic myo-inositol treatment

H. Einat; R. H. Belmaker; M. Kopilov; E. Klein; H. Gazawi; D. Ben-Shachar

doi:10.1016/S0924-977X(99)00047-4

Rat brain monoamines after acute and chronic myo-inositol treatment

H. Einat, R. H. Belmaker, M. Kopilov, E. Klein, H. Gazawi, D. Ben-Shachar

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Inositol was reported to have effects in depression, panic disorder and OCD, and in animal models of depression and anxiety. The present study tested whether inositol treatment alters monoamine systems. Brain areas of rats pre- treated with acute or chronic inositol were analysed by HPLC for monoamines and their metabolites and compared to control animals. Inositol treatment had no significant effect on levels of monoamines, their metabolites, or turnover rates compared to controls.

Original language	English
Pages (from-to)	27-30
Number of pages	4
Journal	European Neuropsychopharmacology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/S0924-977X(99)00047-4
State	Published - 1 Dec 1999

Keywords

Anxiety
Depression
HPLC
Inositol
Monoamines

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

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abstract = "Inositol was reported to have effects in depression, panic disorder and OCD, and in animal models of depression and anxiety. The present study tested whether inositol treatment alters monoamine systems. Brain areas of rats pre- treated with acute or chronic inositol were analysed by HPLC for monoamines and their metabolites and compared to control animals. Inositol treatment had no significant effect on levels of monoamines, their metabolites, or turnover rates compared to controls.",

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AU - Einat, H.

AU - Belmaker, R. H.

AU - Kopilov, M.

AU - Klein, E.

AU - Gazawi, H.

AU - Ben-Shachar, D.

N1 - Funding Information: We were supported by a Stanley Foundation Center grant.

PY - 1999/12/1

Y1 - 1999/12/1

N2 - Inositol was reported to have effects in depression, panic disorder and OCD, and in animal models of depression and anxiety. The present study tested whether inositol treatment alters monoamine systems. Brain areas of rats pre- treated with acute or chronic inositol were analysed by HPLC for monoamines and their metabolites and compared to control animals. Inositol treatment had no significant effect on levels of monoamines, their metabolites, or turnover rates compared to controls.

AB - Inositol was reported to have effects in depression, panic disorder and OCD, and in animal models of depression and anxiety. The present study tested whether inositol treatment alters monoamine systems. Brain areas of rats pre- treated with acute or chronic inositol were analysed by HPLC for monoamines and their metabolites and compared to control animals. Inositol treatment had no significant effect on levels of monoamines, their metabolites, or turnover rates compared to controls.

KW - Anxiety

KW - Depression

KW - HPLC

KW - Inositol

KW - Monoamines

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JO - European Neuropsychopharmacology

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ER -

Rat brain monoamines after acute and chronic myo-inositol treatment

Abstract

Keywords

ASJC Scopus subject areas

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