Rat parotid cell function in vitro following X irradiation in vivo

L. Bodner; B. L. Kuyatt; A. R. Hand; B. J. Baum

doi:10.2307/3576289

Rat parotid cell function in vitro following X irradiation in vivo

L. Bodner, B. L. Kuyatt, A. R. Hand, B. J. Baum

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Abstract

The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K⁺ efflux and reuptake), amino acid transport (α-amino[¹⁴C]isobutyric acid), and an intermediary metabolic response ([¹⁴C]glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.

Original language	English
Pages (from-to)	386-395
Number of pages	10
Journal	Radiation Research
Volume	97
Issue number	2
DOIs	https://doi.org/10.2307/3576289
State	Published - 1 Jan 1984
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Radiation
Radiology Nuclear Medicine and imaging

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title = "Rat parotid cell function in vitro following X irradiation in vivo",

abstract = "The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K+ efflux and reuptake), amino acid transport (α-amino[14C]isobutyric acid), and an intermediary metabolic response ([14C]glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.",

author = "L. Bodner and Kuyatt, {B. L.} and Hand, {A. R.} and Baum, {B. J.}",

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AU - Bodner, L.

AU - Kuyatt, B. L.

AU - Hand, A. R.

AU - Baum, B. J.

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Y1 - 1984/1/1

N2 - The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K+ efflux and reuptake), amino acid transport (α-amino[14C]isobutyric acid), and an intermediary metabolic response ([14C]glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.

AB - The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K+ efflux and reuptake), amino acid transport (α-amino[14C]isobutyric acid), and an intermediary metabolic response ([14C]glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.

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JF - Radiation Research

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Rat parotid cell function in vitro following X irradiation in vivo

Abstract

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