Rational design of platinum(IV) compounds to overcome glutathione-S- transferase mediated drug resistance

Han Ang Wee; Isam Khalaila; Claire S. Allardyce; Lucienne Juillerat-Jeanneret; Paul J. Dyson

doi:10.1021/ja0432618

Rational design of platinum(IV) compounds to overcome glutathione-S- transferase mediated drug resistance

Han Ang Wee, Isam Khalaila, Claire S. Allardyce, Lucienne Juillerat-Jeanneret, Paul J. Dyson

Research output: Contribution to journal › Article › peer-review

305 Scopus citations

Abstract

A rationally designed Pt(IV) anticancer compound is described, employing the novel concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt-based drug-resistance, to cisplatin. Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described.

Original language	English
Pages (from-to)	1382-1383
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	5
DOIs	https://doi.org/10.1021/ja0432618
State	Published - 9 Feb 2005
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ja0432618

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title = "Rational design of platinum(IV) compounds to overcome glutathione-S- transferase mediated drug resistance",

abstract = "A rationally designed Pt(IV) anticancer compound is described, employing the novel concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt-based drug-resistance, to cisplatin. Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described.",

author = "Wee, {Han Ang} and Isam Khalaila and Allardyce, {Claire S.} and Lucienne Juillerat-Jeanneret and Dyson, {Paul J.}",

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AU - Wee, Han Ang

AU - Khalaila, Isam

AU - Allardyce, Claire S.

AU - Juillerat-Jeanneret, Lucienne

AU - Dyson, Paul J.

PY - 2005/2/9

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AB - A rationally designed Pt(IV) anticancer compound is described, employing the novel concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt-based drug-resistance, to cisplatin. Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described.

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Rational design of platinum(IV) compounds to overcome glutathione-S- transferase mediated drug resistance

Abstract

ASJC Scopus subject areas

UN SDGs

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