A rationally designed Pt(IV) anticancer compound is described, employing the novel concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt-based drug-resistance, to cisplatin. Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described.
|Number of pages||2|
|Journal||Journal of the American Chemical Society|
|State||Published - 9 Feb 2005|
ASJC Scopus subject areas
- Chemistry (all)
- Colloid and Surface Chemistry