Reactivation of immunocompetence in spleen cells of aged mice

D. Friedman; V. Keiser; A. Globerson

doi:10.1038/251545a0

Reactivation of immunocompetence in spleen cells of aged mice

D. Friedman
, V. Keiser
, A. Globerson

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

REACTIVITY in both humoral and cellular immune reactions has been shown to decline with age^1-4, but the reasons have not yet been critically established. It could be attributed, at least in part, to thymus involution, since the most prominent reduction in reactivity is shown in thymus-dependent responses⁵. The question is, therefore, whether decreasing immune reactivity results from a decrease in the stem cell pool, or whether it is due to a failure in one of the processes of cell maturation which are affected by the thymus.

Original language	English
Pages (from-to)	545-547
Number of pages	3
Journal	Nature
Volume	251
Issue number	5475
DOIs	https://doi.org/10.1038/251545a0
State	Published - 1 Dec 1974
Externally published	Yes

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title = "Reactivation of immunocompetence in spleen cells of aged mice",

abstract = "REACTIVITY in both humoral and cellular immune reactions has been shown to decline with age1-4, but the reasons have not yet been critically established. It could be attributed, at least in part, to thymus involution, since the most prominent reduction in reactivity is shown in thymus-dependent responses5. The question is, therefore, whether decreasing immune reactivity results from a decrease in the stem cell pool, or whether it is due to a failure in one of the processes of cell maturation which are affected by the thymus.",

author = "D. Friedman and V. Keiser and A. Globerson",

year = "1974",

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T1 - Reactivation of immunocompetence in spleen cells of aged mice

AU - Friedman, D.

AU - Keiser, V.

AU - Globerson, A.

PY - 1974/12/1

Y1 - 1974/12/1

N2 - REACTIVITY in both humoral and cellular immune reactions has been shown to decline with age1-4, but the reasons have not yet been critically established. It could be attributed, at least in part, to thymus involution, since the most prominent reduction in reactivity is shown in thymus-dependent responses5. The question is, therefore, whether decreasing immune reactivity results from a decrease in the stem cell pool, or whether it is due to a failure in one of the processes of cell maturation which are affected by the thymus.

AB - REACTIVITY in both humoral and cellular immune reactions has been shown to decline with age1-4, but the reasons have not yet been critically established. It could be attributed, at least in part, to thymus involution, since the most prominent reduction in reactivity is shown in thymus-dependent responses5. The question is, therefore, whether decreasing immune reactivity results from a decrease in the stem cell pool, or whether it is due to a failure in one of the processes of cell maturation which are affected by the thymus.

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U2 - 10.1038/251545a0

DO - 10.1038/251545a0

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VL - 251

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JO - Nature

JF - Nature

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ER -

Reactivation of immunocompetence in spleen cells of aged mice

Abstract

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