Reactivation of immunocompetence in spleen cells of aged mice

D. Friedman, V. Keiser, A. Globerson

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

REACTIVITY in both humoral and cellular immune reactions has been shown to decline with age1-4, but the reasons have not yet been critically established. It could be attributed, at least in part, to thymus involution, since the most prominent reduction in reactivity is shown in thymus-dependent responses5. The question is, therefore, whether decreasing immune reactivity results from a decrease in the stem cell pool, or whether it is due to a failure in one of the processes of cell maturation which are affected by the thymus.

Original languageEnglish
Pages (from-to)545-547
Number of pages3
JournalNature
Volume251
Issue number5475
DOIs
StatePublished - 1 Dec 1974
Externally publishedYes

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