Reading microdots of a molecularly imprinted polymer by surface-enhanced Raman spectroscopy

Keren Kantarovich, Inbal Tsarfati, Levi A. Gheber, Karsten Haupt, Ilana Bar

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Writing a molecularly imprinted polymer (MIP) by nano-fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces resulted in site-controlled arrays of microdots of approximately 6-12μm in diameter. The monitoring of SERS spectra with a micro-Raman system enabled examining the uptake and release of the S-propranolol imprinting template and allowed imaging individual dots as well as multiple dots in an array, revealing the distribution of the imprinted polymer. This distribution was confirmed by atomic force microscopy, showing that even in dots of <300. nm thickness, corresponding to MIP volumes of 0.5. fl, significantly less than previously reported, the target analyte could be detected and identified. This study shows that nanolithography techniques combined with SERS might open the possibility of miniaturized arrayed MIP sensors with label-free, specific and quantitative detection.

Original languageEnglish
Pages (from-to)809-814
Number of pages6
JournalBiosensors and Bioelectronics
Issue number2
StatePublished - 1 Oct 2010


  • Molecularly imprinted polymer
  • Nano-fountain pen
  • Surface-enhanced Raman scattering

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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