Real-time electromagnetic navigation bronchoscopy to peripheral lung lesion using overlaid CT images: The first human study

Yehuda Schwarz, Joel Greif, Heinrich D. Becker, Armin Ernst, Atul Mehta

Research output: Contribution to journalArticlepeer-review

280 Scopus citations

Abstract

Study objectives: To characterize the feasibility, accuracy, and safety of the superDimension/Bronchus system (SDBS) [superDimension, Ltd; Hertzliya, Israel] in navigating to previously unreachable peripheral lung lesions and obtaining biopsy specimens. Design: Open-label, prospective, controlled clinical study. Setting: Pulmonary institute of a university-affiliated municipal hospital. Patients: Thirteen adult candidates for nonemergency bronchoscopy who gave informed consent to participate. Interventions: The patients underwent flexible bronchoscopy using the SDBS, which is based on real-time CT-guided electromagnetic navigation and is capable of reaching peripheral lung masses beyond the reach of the bronchoscope. A position sensor was used to navigate to and sample the various target lesions for biopsy. Measurements and results: Three-dimensional chest CT was followed by SDBS methodology for marking anatomic landmarks and the target lesion on a virtual bronchoscopy screen and for sampling the lesion. The SDBS assisted in obtaining positive biopsy diagnoses in 9 of 13 cases (69%), with an average navigation accuracy of 5.7 mm. There were no SDBS-related adverse events. Conclusions: The SDBS is safe and effective in navigating to peripheral lung lesions located beyond the optic limits of a standard flexible bronchoscope.

Original languageEnglish
Pages (from-to)988-994
Number of pages7
JournalChest
Volume129
Issue number4
DOIs
StatePublished - 1 Jan 2006
Externally publishedYes

Keywords

  • Navigation bronchoscopy
  • Peripheral lesion

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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