Recent Advancements in Development of Radical Silylation Reactions

Transition metal-free radical hydrosilylation of alkynes and factionalized alkenes tovinylsilanes, organosilanes from alkenes, radical silylative cyclizations for sila heterocycles,aromatic dehydrogenative radical silylation, sila-amino acids, silyl hydroperoxides by usingtransition metal-free reaction conditions such as peroxides, photocatalyst, hydrogen atomtransfer catalyst, radical initiators have become one of the most important and useful methodologiesfor the construction of C-Si bonds for their synthetic applications. In order to demonstratethe growth in this area, this review highlights the last twenty years of success in thefields of silylation of aromatics, silylative cyclizations of sila heterocycles, synthesis of vinylsilanesby hydrosilylation of alkynes, and functionalized alkenes, organosilanes from alkenesand dehydrogenative approaches for vinylsilanes involving radical mechanisms. Webelieve that summarizing these methods would be very useful for the chemists who are interested in the synthesis oforganosilicon compounds for drug discovery or the development of silicon-based materials for industrial applications.