Recent Advances in Transition Metal-Catalyzed Domino-Cyclization Strategies for Functionalized Heterocyclic/Carbocyclic Compounds

The discovery of the Domino reaction offers a useful strategy to the scientific community. From the beginning, it has received much attention in numerous advances for organic synthesis. Especially, for the constructive cyclization via multiple C−C and C-heteroatom bond formation, the Domino-Heck coupling reaction has become an essential tool in organic chemistry. In the case of drug synthesis, different natural products and biologically relevant scaffolds are achieved by employing the Domino-cyclization technique. Palladium or nickel-based intramolecular coupling reactions have been associated with many developing methods which lead to important carbo or heterocyclic scaffolds. In this account, metal-catalyzed intramolecular cyclization is an emerging tool to access several heterocyclic scaffolds such as coumarins, quinolines, piperidines, indoles spiro and fused polycyclic rings. In this review, we have attempted to highlight the recent advances in metal-mediated Domino cyclization reaction over the past few years.