Recent trends in biodegradable polyester nanomaterials for cancer therapy

Piyush Kumar Gupta, Rekha Gahtori, Kavitha Govarthanan, Vineeta Sharma, Sreenath Pappuru, Soumya Pandit, Abhilasha Singh Mathuriya, Sunny Dholpuria, Dillip Kumar Bishi

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Biodegradable polyester nanomaterials-based drug delivery vehicles (DDVs) have been largely used in most of the cancer treatments due to its high biological performance and wider applications. In several previous studies, various biodegradable and biocompatible polyester backbones were used which are poly(lactic acid) (PLA), poly(ε-caprolactone) (PCL), poly(propylene fumarate) (PPF), poly(lactic-co-glycolic acid) (PLGA), poly(propylene carbonate) (PPC), polyhydroxyalkanoates (PHA), and poly(butylene succinate) (PBS). These polyesters were fabricated into therapeutic nanoparticles that carry drug molecules to the target site during the cancer disease treatment. In this review, we elaborately discussed the chemical synthesis of different synthetic polyesters and their use as nanodrug carriers (NCs) in cancer treatment. Further, we highlighted in brief the recent developments of metal-free semi-aromatic polyester nanomaterials along with its role as cancer drug delivery vehicles.

Original languageEnglish
Article number112198
JournalMaterials Science and Engineering C
Volume127
DOIs
StatePublished - 1 Aug 2021
Externally publishedYes

Keywords

  • Cancer therapy
  • Clinical application
  • Drug delivery
  • Metal-free synthesis
  • Polyester nanomaterials

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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