Recent trends in biodegradable polyester nanomaterials for cancer therapy

Piyush Kumar Gupta; Rekha Gahtori; Kavitha Govarthanan; Vineeta Sharma; Sreenath Pappuru; Soumya Pandit; Abhilasha Singh Mathuriya; Sunny Dholpuria; Dillip Kumar Bishi

doi:10.1016/j.msec.2021.112198

Recent trends in biodegradable polyester nanomaterials for cancer therapy

Piyush Kumar Gupta, Rekha Gahtori, Kavitha Govarthanan, Vineeta Sharma, Sreenath Pappuru, Soumya Pandit, Abhilasha Singh Mathuriya, Sunny Dholpuria, Dillip Kumar Bishi

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Biodegradable polyester nanomaterials-based drug delivery vehicles (DDVs) have been largely used in most of the cancer treatments due to its high biological performance and wider applications. In several previous studies, various biodegradable and biocompatible polyester backbones were used which are poly(lactic acid) (PLA), poly(ε-caprolactone) (PCL), poly(propylene fumarate) (PPF), poly(lactic-co-glycolic acid) (PLGA), poly(propylene carbonate) (PPC), polyhydroxyalkanoates (PHA), and poly(butylene succinate) (PBS). These polyesters were fabricated into therapeutic nanoparticles that carry drug molecules to the target site during the cancer disease treatment. In this review, we elaborately discussed the chemical synthesis of different synthetic polyesters and their use as nanodrug carriers (NCs) in cancer treatment. Further, we highlighted in brief the recent developments of metal-free semi-aromatic polyester nanomaterials along with its role as cancer drug delivery vehicles.

Original language	English
Article number	112198
Journal	Materials Science and Engineering C
Volume	127
DOIs	https://doi.org/10.1016/j.msec.2021.112198
State	Published - 1 Aug 2021
Externally published	Yes

Keywords

Cancer therapy
Clinical application
Drug delivery
Metal-free synthesis
Polyester nanomaterials

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.msec.2021.112198

Cite this

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title = "Recent trends in biodegradable polyester nanomaterials for cancer therapy",

abstract = "Biodegradable polyester nanomaterials-based drug delivery vehicles (DDVs) have been largely used in most of the cancer treatments due to its high biological performance and wider applications. In several previous studies, various biodegradable and biocompatible polyester backbones were used which are poly(lactic acid) (PLA), poly(ε-caprolactone) (PCL), poly(propylene fumarate) (PPF), poly(lactic-co-glycolic acid) (PLGA), poly(propylene carbonate) (PPC), polyhydroxyalkanoates (PHA), and poly(butylene succinate) (PBS). These polyesters were fabricated into therapeutic nanoparticles that carry drug molecules to the target site during the cancer disease treatment. In this review, we elaborately discussed the chemical synthesis of different synthetic polyesters and their use as nanodrug carriers (NCs) in cancer treatment. Further, we highlighted in brief the recent developments of metal-free semi-aromatic polyester nanomaterials along with its role as cancer drug delivery vehicles.",

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author = "Gupta, {Piyush Kumar} and Rekha Gahtori and Kavitha Govarthanan and Vineeta Sharma and Sreenath Pappuru and Soumya Pandit and Mathuriya, {Abhilasha Singh} and Sunny Dholpuria and Bishi, {Dillip Kumar}",

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doi = "10.1016/j.msec.2021.112198",

language = "English",

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T1 - Recent trends in biodegradable polyester nanomaterials for cancer therapy

AU - Gupta, Piyush Kumar

AU - Gahtori, Rekha

AU - Govarthanan, Kavitha

AU - Sharma, Vineeta

AU - Pappuru, Sreenath

AU - Pandit, Soumya

AU - Mathuriya, Abhilasha Singh

AU - Dholpuria, Sunny

AU - Bishi, Dillip Kumar

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Biodegradable polyester nanomaterials-based drug delivery vehicles (DDVs) have been largely used in most of the cancer treatments due to its high biological performance and wider applications. In several previous studies, various biodegradable and biocompatible polyester backbones were used which are poly(lactic acid) (PLA), poly(ε-caprolactone) (PCL), poly(propylene fumarate) (PPF), poly(lactic-co-glycolic acid) (PLGA), poly(propylene carbonate) (PPC), polyhydroxyalkanoates (PHA), and poly(butylene succinate) (PBS). These polyesters were fabricated into therapeutic nanoparticles that carry drug molecules to the target site during the cancer disease treatment. In this review, we elaborately discussed the chemical synthesis of different synthetic polyesters and their use as nanodrug carriers (NCs) in cancer treatment. Further, we highlighted in brief the recent developments of metal-free semi-aromatic polyester nanomaterials along with its role as cancer drug delivery vehicles.

AB - Biodegradable polyester nanomaterials-based drug delivery vehicles (DDVs) have been largely used in most of the cancer treatments due to its high biological performance and wider applications. In several previous studies, various biodegradable and biocompatible polyester backbones were used which are poly(lactic acid) (PLA), poly(ε-caprolactone) (PCL), poly(propylene fumarate) (PPF), poly(lactic-co-glycolic acid) (PLGA), poly(propylene carbonate) (PPC), polyhydroxyalkanoates (PHA), and poly(butylene succinate) (PBS). These polyesters were fabricated into therapeutic nanoparticles that carry drug molecules to the target site during the cancer disease treatment. In this review, we elaborately discussed the chemical synthesis of different synthetic polyesters and their use as nanodrug carriers (NCs) in cancer treatment. Further, we highlighted in brief the recent developments of metal-free semi-aromatic polyester nanomaterials along with its role as cancer drug delivery vehicles.

KW - Cancer therapy

KW - Clinical application

KW - Drug delivery

KW - Metal-free synthesis

KW - Polyester nanomaterials

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DO - 10.1016/j.msec.2021.112198

M3 - Review article

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AN - SCOPUS:85107074515

SN - 0928-4931

VL - 127

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

M1 - 112198

ER -

Recent trends in biodegradable polyester nanomaterials for cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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