Recent Update on Active Biological Molecules in Generating the Anticancerous Therapeutic Potential of Garcinia mangostana

Neha Verma, Soumya Pandit, Anil Kumar, Gulab Yadav, Shiv Kumar Giri, Dibyajit Lahiri, Zulhisyam Abdul Kari, Ram Prasad, KanuPriya

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

The Garciniamangostana Linn (Mangosteen) is also called as “Queen of Fruits” in Malaysia. It is found in the region of Southeast Asia. It is a medicinal plant that has been used to treat cancer in a variety of cell lines. The mangosteen pericarp possesses distinctive biological properties like anticancer or antitumoral and antioxidant. It has a distinct sweet and sour taste, rich in biological compounds like xanthones. It exhibits various properties like apoptotic in tumor cells which leads to the suppression of their growth and results in their various sizes. The primary purpose of this review article is to summarize the valuable results covered by the researchers so far in the Garcinia mangostana extract and its compound like xanthones. Our focus was to explain the role of the phytoconstituent molecules in invading the cancer pathways to combat the expansion of cells. Furthermore, we still feel that there is a scope for more in silico and in vivo studies to understand and identify the specific site of action in tumoral cells and their mechanistic pathways. In conclusion, Garcinia mangostana can act as an anticancer agent by attacking various molecular pathways. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)4724-4744
Number of pages21
JournalApplied Biochemistry and Biotechnology
Volume194
Issue number10
DOIs
StatePublished - 1 Oct 2022
Externally publishedYes

Keywords

  • Anticancer
  • Biological properties
  • Garcinia mangostana
  • Mangosteen
  • Xanthones

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Bioengineering
  • Molecular Biology
  • Biochemistry
  • Biotechnology

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