Rechallenge With Crystalline Niacin After Drug-Induced Hepatitis From Sustained-Release Niacin

Yaakov Henkin, Karen C. Johnson, Jere P. Segrest

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Niacin (nicotinic acid) is available in several forms, including crystalline preparations and various types of sustained-release preparations. Evidence exists that sustained-release niacin, with respect to both dosage and severity, is more hepatotoxic than crystalline niacin. Three patients who developed hepatitis during treatment with sustained-release niacin were rechallenged with equivalent or higher doses of crystalline niacin, with no evidence of recurring hepatocellular damage. Although the mechanism for niacin-induced hepatitis is unknown, these cases support previous observations that crystalline niacin may be less hepatotoxic than sustained-release preparations in certain patients.

Original languageEnglish
Pages (from-to)241-243
Number of pages3
JournalJAMA - Journal of the American Medical Association
Issue number2
StatePublished - 11 Jul 1990
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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