TY - JOUR
T1 - Rechallenge With Crystalline Niacin After Drug-Induced Hepatitis From Sustained-Release Niacin
AU - Henkin, Yaakov
AU - Johnson, Karen C.
AU - Segrest, Jere P.
PY - 1990/7/11
Y1 - 1990/7/11
N2 - Niacin (nicotinic acid) is available in several forms, including crystalline preparations and various types of sustained-release preparations. Evidence exists that sustained-release niacin, with respect to both dosage and severity, is more hepatotoxic than crystalline niacin. Three patients who developed hepatitis during treatment with sustained-release niacin were rechallenged with equivalent or higher doses of crystalline niacin, with no evidence of recurring hepatocellular damage. Although the mechanism for niacin-induced hepatitis is unknown, these cases support previous observations that crystalline niacin may be less hepatotoxic than sustained-release preparations in certain patients.
AB - Niacin (nicotinic acid) is available in several forms, including crystalline preparations and various types of sustained-release preparations. Evidence exists that sustained-release niacin, with respect to both dosage and severity, is more hepatotoxic than crystalline niacin. Three patients who developed hepatitis during treatment with sustained-release niacin were rechallenged with equivalent or higher doses of crystalline niacin, with no evidence of recurring hepatocellular damage. Although the mechanism for niacin-induced hepatitis is unknown, these cases support previous observations that crystalline niacin may be less hepatotoxic than sustained-release preparations in certain patients.
UR - http://www.scopus.com/inward/record.url?scp=0025295546&partnerID=8YFLogxK
U2 - 10.1001/jama.1990.03450020093033
DO - 10.1001/jama.1990.03450020093033
M3 - Article
AN - SCOPUS:0025295546
SN - 0098-7484
VL - 264
SP - 241
EP - 243
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 2
ER -
