Abstract
Objective: To report intractable life-threatening pulmonary hemorrhage after cardiac surgery in an infant who was treated successfully with recombinant activated factor VII (rFVIIa). Design: Descriptive case report. Setting: An 18-bed pediatric intensive care unit at a tertiarycare children's hospital. Patient: A 10-wk-old child with acute life-threatening pulmonary hemorrhage after cardiac surgery. Interventions: General supportive intensive care. Measurements and Main Results: Care included mechanical ventilatory support, inotropic support, and concurrent treatment with blood products (packed cells, platelet concentrates, and plasma-derived products), as well as aprotinin and desmopressin to improve hemostasis. The addition of rFVIIa resulted in complete resolution of the hemorrhage. Conclusions: rFVIIa should be considered as a possible novel therapeutic approach to be used as rescue therapy for patients presenting with massive life-threatening hemorrhage progressing into hemorrhagic shock. Further controlled trials to elucidate the safety of this treatment are warranted. (Pediatr Crit Care Med 2003; 4:444 -446).
| Original language | English |
|---|---|
| Pages (from-to) | 444-446 |
| Number of pages | 3 |
| Journal | Pediatric Critical Care Medicine |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Dec 2003 |
| Externally published | Yes |
Keywords
- Activated factor seven
- Cardiac surgery
- Pulmonary hemorrhage
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Critical Care and Intensive Care Medicine
